ORAL MEDICINE : Fanconi Anemia: main oral manifestations

Fanconi Anemia is a recessive and rare genetic disorder, characterized by chromosomal instability that induces congenital alterations in individuals. 

Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia.

oral-medicine



Some of these diseases develop mainly after bone marrow transplantation. The aim of this critical review of the literature was to discourse about the main oral manifestations and their involvement in the health of individuals who are ill with Fanconi Anemia. 

The clinical oral findings described in the literature include periodontal changes, such as gingivitis and aggressive periodontitis, recurrent aphthous ulcers and traumatic lesions. 




Anna Clara Duszczak D'AGULHAM, Cassiano Lima CHAIBEN, Antônio Adilson Soares de LIMA, Cassius Carvalho TORRES-PEREIRA, Maria Ângela Naval MACHADO



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